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DTSTAMP:20250313T043650Z
DESCRIPTION: \n\n \n\nTitle: Mechanistic mathematical modelling of granulop
 oiesis: Elucidating the negative feedback interactions between G-CSF and n
 eutrophils and the physiological determinants of G-CSF pharmacokinetics \n
 \n \n\nAbstract: Pharmacokinetic (PK) models describing the disposition of
  drugs within the body are generally constructed from surrogate data using
  a variety of methods. Unfortunately\, traditional PK models are largely a
 bsent of the mechanisms driving drug interactions. Worse\, in some cases\,
  the classic PK modelling approach can lead to erroneous conclusions about
  the physiological system at hand. In this talk\, I will focus on the deve
 lopment of a physiological model of the production of neutrophils in the b
 one marrow. The model is a set of delay differential equations (DDEs) with
  state-dependent delays and a variable maturation rate\, constructed direc
 tly from the physiology of the hematopoietic system. \n\n \n\nThe process 
 of producing a neutrophil is mediated by the endogenous cytokine granulocy
 te colony-stimulating factor (G-CSF)\, whose PKs are dictated by the negat
 ive feedback interactions between G-CSF and the neutrophil lineage. Here\,
  I will detail the determination of a novel PK model of G-CSF using the DD
 E physiological model as a basis\, and show how traditional PK approaches 
 have previously mischaracterised the elimination kinetics of G-CSF. I will
  also touch on how\, due to its careful construction from the mechanisms o
 f the blood system\, the combined model can be applied to answer fundament
 al physiological questions\, and discuss future directions.\n
DTSTART:20161124T211500Z
DTEND:20161124T211500Z
LOCATION:Room 920\, Burnside Hall\, CA\, QC\, Montreal\, H3A 0B9\, 805 rue 
 Sherbrooke Ouest
SUMMARY:Morgan Craig - Harvard
URL:/mathstat/channels/event/morgan-craig-harvard-2641
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