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UID:20250312T172539EDT-5882w5XCMx@132.216.98.100
DTSTAMP:20250312T212539Z
DESCRIPTION:The Neuro's Olszewski Lecture\, established in 1986\, honours D
 r. Jerzy Olszewski (1913–1964)\, a pioneering neuroanatomist and neuropath
 ologist. Invited to The Neuro by Dr. Wilder Penfield in 1948\, Olszewski c
 ollaborated on the seminal Cytoarchitecture of the Human Brain Stem\, adva
 ncing the understanding of brainstem structures and cementing his legacy i
 n neuroscience.\n\n\nTo attend in person\, register here.\n\nTo view the l
 ecture online\, click here.\n\n\nXiaowei Zhuang \n\nHoward Hughes Medical 
 Institute\, Harvard University\n\nAbstract: Cell and tissue functions aris
 e from the coordinated activities of thousands of different genes. Underst
 anding these functions requires imaging at the genome scale\, which advanc
 es knowledge in many areas of biology\, from the regulation of gene expres
 sion in cells to the development of cell fate and the organization of cell
  types in complex tissues. A single-cell genome-scale imaging method\, mul
 tiplexed error-robust fluorescence in situ hybridization (MERFISH)\, was d
 eveloped to enable spatially resolved single-cell transcriptomics\, epigen
 omics\, 3D-genomics\, and functional genomics. This method allows for sing
 le-cell gene-expression profiling in intact tissues\, facilitating the ide
 ntification\, spatial mapping\, and functional investigation of distinct c
 ell types within those tissues. Using this approach\, molecularly defined\
 , spatially resolved\, and functionally annotated cell atlases of the brai
 n have been created. This lecture will describe the MERFISH technology and
  its applications\, with a particular focus on mapping the molecular\, spa
 tial\, and functional organizations of distinct cell types in the brain.\n
DTSTART:20250327T200000Z
DTEND:20250327T210000Z
LOCATION:de Grandpre Communications Centre\, Montreal Neurological Institut
 e\, CA\, QC\, Montreal\, H3A 2B4\, 3801 rue University
SUMMARY:Olszewski Lecture: Spatially Resolved Single-Cell Genomics & Cell A
 tlas of the Brain
URL:/medhealthsci-gradstudies/channels/event/olszewski
 -lecture-spatially-resolved-single-cell-genomics-cell-atlas-brain-361354
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