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Bacteria that evolve resistance to antimicrobial therapies may be able to evade natural immune peptides. However, bacteria can evolve resistance to AMPs under strong selective pressure in vitro.

In 2003, Graham Bell at 9I制作厂免费 and Pierre-Henri Gouyon at Universit茅 Paris-Sud published an article voicing another concern鈥攖hat when cross-resistance evolved, as it surely would, bacteria might become resistant not only to AMPs adopted for therapeutic use, but also to endogenous human peptides.