/tropmed/fr/aggregator Centre J.D. MacLean pour la médecine tropicale et géographique - flux agrégés fr https://pubmed.ncbi.nlm.nih.gov/41156739/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1zSVwQViw4htk0ptJE-rdb4g98Hn0Vy51ceCnixBnFkL6ILsbf&fc=20201106102241&ff=20251030004755&v=2.18.0.post22+67771e2 Leishmaniasis is a vector-borne parasitic disease caused by Leishmania spp., transmitted to humans by phlebotomine sand flies. The development of Leishmania into infective metacyclic promastigotes occurs within the sand fly gut, where the bacterial microbiota plays a pivotal role in parasite development and transmission dynamics. This study aimed to characterize the gut bacterial composition of phlebotomine sand flies collected from both endemic (Lalla Aaziza) and non-endemic (Marrakech) regions... Wed, 29 Oct 2025 06:00:00 -0400 https://pubmed.ncbi.nlm.nih.gov/41156623/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1zSVwQViw4htk0ptJE-rdb4g98Hn0Vy51ceCnixBnFkL6ILsbf&fc=20201106102241&ff=20251030004755&v=2.18.0.post22+67771e2 Phlebotomine-borne diseases, transmitted by sand flies, cause significant public health burdens worldwide. In Morocco, Phlebotomus papatasi is a primary vector for Leishmania major and phleboviruses. Despite extensive research in other countries, entomopathogenic parasite investigations in P. papatasi have not been conducted in Morocco until now. This study performed proteomic analysis of female P. papatasi collected from four Moroccan localities using liquid chromatography-tandem mass... Wed, 29 Oct 2025 06:00:00 -0400 https://pubmed.ncbi.nlm.nih.gov/41144209/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1zSVwQViw4htk0ptJE-rdb4g98Hn0Vy51ceCnixBnFkL6ILsbf&fc=20201106102241&ff=20251028002144&v=2.18.0.post22+67771e2 Cryptosporidiosis threatens the lives of young children in developing countries and newborn calves around the world. No vaccine or therapy can prevent or cure this diarrhea-inducing enteric disease caused by Cryptosporidium spp. protozoan parasites. There is an essential need to discover new therapeutic drugs efficient in reducing parasite burden in infected individuals. Research therefore relies on reliable small animal models of cryptosporidiosis. Here, we present excellent mouse models which... Mon, 27 Oct 2025 06:00:00 -0400 https://pubmed.ncbi.nlm.nih.gov/41081009/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1zSVwQViw4htk0ptJE-rdb4g98Hn0Vy51ceCnixBnFkL6ILsbf&fc=20201106102241&ff=20251014005307&v=2.18.0.post9+e462414 CONCLUSIONS: The multifactorial nature of linear growth faltering in these preschool children differed by season. The negative impact of diarrhea emerged only in the rainy season, but the negative impact of sugar intake and the positive impact of fat intake emerged in both seasons. Mon, 13 Oct 2025 06:00:00 -0400 https://pubmed.ncbi.nlm.nih.gov/41072706/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1zSVwQViw4htk0ptJE-rdb4g98Hn0Vy51ceCnixBnFkL6ILsbf&fc=20201106102241&ff=20251011011238&v=2.18.0.post9+e462414 Leishmania donovani is the causative agent of visceral leishmaniasis, a tropical disease affecting millions worldwide. While proteomic studies of Leishmania species have been conducted, the organization of protein-protein interaction (PPI) networks in L. donovani remains largely unexplored. Here, we present a protein interaction network for L. donovani generated through size-exclusion chromatography coupled with mass spectrometry (SEC-MS) and computational analysis. We quantified 3,468 proteins... Fri, 10 Oct 2025 06:00:00 -0400 https://pubmed.ncbi.nlm.nih.gov/41052060/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1zSVwQViw4htk0ptJE-rdb4g98Hn0Vy51ceCnixBnFkL6ILsbf&fc=20201106102241&ff=20251007003115&v=2.18.0.post9+e462414 CONCLUSIONS: This study demonstrates the real-world impact of SVR on liver-related mortality and highlights the value of early treatment and continued support for populations who are marginalised. Mon, 06 Oct 2025 06:00:00 -0400 https://pubmed.ncbi.nlm.nih.gov/41030586/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1zSVwQViw4htk0ptJE-rdb4g98Hn0Vy51ceCnixBnFkL6ILsbf&fc=20201106102241&ff=20251002001916&v=2.18.0.post9+e462414 Background: Primary pulmonary cystic echinococcosis (CE) is a zoonotic disease often caused by Echinococcus granulosus sensu lato complex. Although rare in North America, it can present significant diagnostic and therapeutic challenges. Case Presentation: We report a 36-year-old male from Quebec, Canada, with locally acquired primary pulmonary CE who presented to the emergency department with a two-month history of shortness of breath, cough, and hemoptysis. Laboratory investigations showed mild... Wed, 01 Oct 2025 06:00:00 -0400 https://pubmed.ncbi.nlm.nih.gov/41026524/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1zSVwQViw4htk0ptJE-rdb4g98Hn0Vy51ceCnixBnFkL6ILsbf&fc=20201106102241&ff=20251001010843&v=2.18.0.post9+e462414 Type 1 diabetes (T1D) is characterized by the autoimmune destruction of most insulin-producing β-cells, along with dysregulated glucagon secretion from pancreatic α-cells. We conducted an integrated analysis that combines electrophysiological and transcriptomic profiling, along with machine learning, of islet cells from T1D donors. The few surviving β-cells exhibit altered electrophysiological properties and transcriptomic signatures indicative of increased antigen presentation, metabolic... Tue, 30 Sep 2025 06:00:00 -0400 https://pubmed.ncbi.nlm.nih.gov/41025660/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1zSVwQViw4htk0ptJE-rdb4g98Hn0Vy51ceCnixBnFkL6ILsbf&fc=20201106102241&ff=20251001010843&v=2.18.0.post9+e462414 Antimicrobial combinations resulting in synergy against Staphylococcus aureus are desirable for improving clinical efficacy in the treatment of severe infections caused by this pathogen. Despite an existing biological rationale for the combination of cefazolin and linezolid for methicillin-susceptible S. aureus (MSSA), this combination has yet to be evaluated for in vitro synergy. We employed the checkerboard and E-test methods of synergy assessment to evaluate cefazolin in combination with... Tue, 30 Sep 2025 06:00:00 -0400 https://pubmed.ncbi.nlm.nih.gov/40973705/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1zSVwQViw4htk0ptJE-rdb4g98Hn0Vy51ceCnixBnFkL6ILsbf&fc=20201106102241&ff=20250921020751&v=2.18.0.post9+e462414 No abstract Fri, 19 Sep 2025 06:00:00 -0400