Boris Bernhardt, PhD
Boris Bernhardt is Associate Professor of Neurology and Neurosurgery and a Canada Research Chair at the Montreal Neurological Institute, 9I制作厂免费, in Montreal, Quebec, Canada.
His lab studies the role of structural and functional network organization in human cognition in neurotypical individuals and populations with atypical brain development, notably people with epilepsy and autism. To this end, they develop neuroinformatics approaches that integrate connectome models with multimodal neuroimaging, electrophysiology, histology, and transcriptomics techniques.
His team made multiple tools for multiscale neuroscience openly available (e.g., , , , , , ) and they shared several high-def datasets with the community (, ).
Boris Bernhardt is work package leader of the Hiball project (l) and Associate Leader of the Neuroinformatics & Computational Modelling theme of Healthy Brains and Healthy Lives at 9I制作厂免费.
Paquola C, Garber M, Fr脙陇ssle S, Royer J, Zhou Y, Tavakol S, Rodriguez-Cruces R, Cabalo DG, Valk S, Eickhoff S, Margulies DS, Evans A, Amunts K, Jefferies E, Smallwood J, Bernhardt BC (2025) The architecture of the human default mode network explored through cytoarchitecture, wiring and signal flow. Nature Neuroscience.
Xie K, Royer J, Rodriguez-Cruces R, Horwood L, Ngo A, Arafat T, Auer H, Sahlas E, Chen J, Zhou Y, Valk SL, Hong SJ, Frauscher B, Pana R, Bernasconi A, Bernasconi N, Concha L, Bernhardt BC (2025) Temporal Lobe Epilepsy Perturbs the Brain-Wide Excitation-Inhibition Balance: Associations with Microcircuit Organization, Clinical Parameters, and Cognitive Dysfunction. Advanced Science. doi: 10.1002/advs.202406835.
Cabalo DG, DeKraker J, Royer J, Xie K, Tavakol S, Rodr脙颅guez-Cruces R, Bernasconi A, Bernasconi N, Weil A, Pana R, Frauscher B, Caciagli L, Jefferies E, Smallwood J, Bernhardt BC. (2024) Differential reorganization of episodic and semantic memory systems in epilepsy-related mesiotemporal pathology. doi: 10.1093/brain/awae197.
Larivi脙篓re S, Park BY, Royer J, DeKraker J, Ngo A, Sahlas E, Chen J, Rodr脙颅guez-Cruces R, Weng Y, Frauscher B, Liu R, Wang Z, Shafiei G, Mi脜隆i脛鈥� B, Bernasconi A, Bernasconi N, Fox MD, Zhang Z, Bernhardt BC (2024) Connectome reorganization associated with temporal lobe pathology and its surgical resection. doi: 10.1093/brain/awae141
Royer J, Larivi脙篓re S, Rodriguez-Cruces R, Cabalo DG, Tavakol S, Auer H, Ngo A, Park BY, Paquola C, Smallwood J, Jefferies E, Caciagli L, Bernasconi A, Bernasconi N, Frauscher B, Bernhardt BC. (2023) Cortical microstructural gradients capture memory network reorganization in temporal lobe epilepsy.Brain. doi: 10.1093/brain/awad125.
Larivi脙篓re S, Bayrak 脜啪, Vos de Wael R, Benkarim O, Herholz P, Rodriguez-Cruces R, Paquola C, Hong SJ, Misic B, Evans AC, Valk SL, Bernhardt BC (2023) BrainStat: A toolbox for brain-wide statistics and multimodal feature associations. Neuroimage. doi: 10.1016/j.neuroimage.2022.119807
Cruces RR, Royer J, Herholz P, Larivi脙篓re S, Vos de Wael R, Paquola C, Benkarim O, Park BY, Degr脙漏-Pelletier J, Nelson MC, DeKraker J, Leppert IR, Tardif C, Poline JB, Concha L, Bernhardt BC. (2022) Micapipe: A pipeline for multimodal neuroimaging and connectome analysis. doi: 10.1016/j.neuroimage.2022.119612
Paquola C, Amunts K, Evans A, Smallwood J, Bernhardt B. (2022) Closing the mechanistic gap: the value of microarchitecture in understanding cognitive networks. Trends Cogn Sci. doi: 10.1016/j.tics.2022.07.001
Bernhardt BC, Smallwood J, Keilholz S, Margulies DS. (2022) Gradients in brain organization. Neuroimage. doi: 10.1016/j.neuroimage.2022.118987
Larivi脙篓re S, Paquola C, Park BY, Royer J, Wang Y, Benkarim O, Vos de Wael R, Valk SL, Thomopoulos SI, Kirschner M, Lewis LB, Evans AC, Sisodiya SM, McDonald CR, Thompson PM, Bernhardt BC (2021) The ENIGMA Toolbox: multiscale neural contextualization of multisite neuroimaging datasets. Nat Methods. doi: 10.1038/s41592-021-01186-4.
Park BY, Hong SJ, Valk SL, Paquola C, Benkarim O, Bethlehem RAI, Di Martino A, Milham MP, Gozzi A, Yeo BTT, Smallwood J, Bernhardt BC. (2021) Differences in subcortico-cortical interactions identified from connectome and microcircuit models in autism. Nat Commun. doi: 10.1038/s41467-021-21732-0.
Paquola C, Vos De Wael R, Wagstyl K, Bethlehem RAI, Hong SJ, Seidlitz J, Bullmore ET, Evans AC, Misic B, Margulies DS, Smallwood J, Bernhardt BC. (2019) Microstructural and functional gradients are increasingly dissociated in transmodal cortices. PLoS Biol. doi: 10.1371/journal.pbio.3000284
Hong SJ, Vos de Wael R, Bethlehem RAI, Lariviere S, Paquola C, Valk SL, Milham MP, Di Martino A, Margulies DS, Smallwood J, Bernhardt BC. (2019) Atypical functional connectome hierarchy in autism. Nat Commun. doi: 10.1038/s41467-019-08944-1
Open Access toolboxes:
Hippomaps:
DeKraker J, Cabalo DG, Royer J, Khan AR, Karat B, Benkarim O, Rodriguez-Cruces R, Frauscher B, Pana R, Hansen JY, Misic B, Valk SL, Kirschner M, Bernasconi A, Bernasconi N, Muenzig S, Axer M, Amunts K, Evans AC, Bernhardt BC (2024) HippoMaps: multiscale cartography of human hippocampal organization. biorxiv.
BrainStat:
Lariviere S, Bayrak S, Vos de Wael R, Benkarim O, Herholz P, Rodriguez-Cruces R, Paquola C, Hong S, Misic B, Evans AC, Valk SL, Bernhardt BC (2023) BrainStat: A toolbox for brain-wide statistics and neuroscientific contextualization. Neuroimage. 266: 119807
MicaPipe:
Rodriguez-Cruces R, Royer J, Herholz P, Lariviere S, Vos de Wael R, Paquola C, Benkarim O, Park B, Degre-Pelletier J, Nelson MC, DeKraker J, Leppert IR, Tardif CL, Poline JB, Concha L, Bernhardt BC (2022) Micapipe: a pipeline for multimodal neuroimaging and connectome analysis. Neuroimage. 263: 119612
Enigma-toolbox:
Lariviere S, Paquola C, Park B, Royer J, Wang Y, Benkarim O, Vos de Wael R, Valk S, Thomopoulos SI, Kirschner M, ENIGMA, Sisodiya S, McDonald CR, Thompson PM, Bernhardt BC (2021) The ENIGMA toolbox: multiscale neural contextualization of multisite neuroimaging datasets. Nature Methods, 18: 698-700
BrainSpace:
Vos de Wael R, Benkarim O, Paquola C, Larivi脙篓re S, Royer J, Tavakol S, Xu T, Hong S, Langs G, Valk S, Misic B, Milham M, Margulies D, Smallwood J, Bernhardt BC (2020) BrainSpace: a toolbox for the analysis of macroscale gradients in neuroimaging and connectomics datasets. Comms Biology, 3(1): 103-112
BigBrainWarp:
Paquola C, Royer J, Lewis L, Lepage Claude, Glatard T, Wagstyl K, DeKraker K, Toussaint PJ, Valk S, Collins DL, Khan AR, Amunts K, Evans A, Dickscheid T, Bernhardt BC (2021) The BigBrainWarp toolbox for integration of BigBrain 3D histology with multimodal neuroimaging. eLife, 10: e70119
