Boris Bernhardt
Boris Bernhardt, Ph. D., professeur adjoint de neurologie et de neurochirurgie et titulaire d鈥檜ne chaire de recherche du Canada, dirige le au Neuro (Institut-h么pital neurologique de Montr茅al).
Dans son laboratoire, on 茅tudie le r么le de l鈥檕rganisation structurelle et fonctionnelle des r茅seaux c茅r茅braux dans la cognition d鈥檕rdre sup茅rieur chez des populations saines et malades, notamment dans l鈥櫭﹑ilepsie et l鈥檃utisme. Pour ce faire, on a d茅velopp茅 des m茅thodes neuro-informatiques qui int猫grent des mod猫les de connectome 脿 grande 茅chelle bas茅s sur la neuro-imagerie, l鈥檋istologie 3D et transcriptomique.
Boris Bernhardt a publi茅 plus de 130 articles avec comit茅 de lecture et son 茅quipe a mis en libre acc猫s plusieurs progiciels et ensembles de donn茅es pour la cartographie multi-茅chelle du cerveau humain, entre autres, , , ).
Paquola C, Garber M, Fr脙陇ssle S, Royer J, Zhou Y, Tavakol S, Rodriguez-Cruces R, Cabalo DG, Valk S, Eickhoff S, Margulies DS, Evans A, Amunts K, Jefferies E, Smallwood J, Bernhardt BC (2025) The architecture of the human default mode network explored through cytoarchitecture, wiring and signal flow. Nature Neuroscience.听
Xie K, Royer J, Rodriguez-Cruces R, Horwood L, Ngo A, Arafat T, Auer H, Sahlas E, Chen J, Zhou Y, Valk SL, Hong SJ, Frauscher B, Pana R, Bernasconi A, Bernasconi N, Concha L, Bernhardt BC (2025) Temporal Lobe Epilepsy Perturbs the Brain-Wide Excitation-Inhibition Balance: Associations with Microcircuit Organization, Clinical Parameters, and Cognitive Dysfunction. Advanced Science. doi: 10.1002/advs.202406835.
Cabalo DG, DeKraker J, Royer J, Xie K, Tavakol S, Rodr脙颅guez-Cruces R, Bernasconi A, Bernasconi N, Weil A, Pana R, Frauscher B, Caciagli L, Jefferies E, Smallwood J, Bernhardt BC. (2024) Differential reorganization of episodic and semantic memory systems in epilepsy-related mesiotemporal pathology. doi: 10.1093/brain/awae197.
Larivi脙篓re S, Park BY, Royer J, DeKraker J, Ngo A, Sahlas E, Chen J, Rodr脙颅guez-Cruces R, Weng Y, Frauscher B, Liu R, Wang Z, Shafiei G, Mi脜隆i脛鈥� B, Bernasconi A, Bernasconi N, Fox MD, Zhang Z, Bernhardt BC (2024) Connectome reorganization associated with temporal lobe pathology and its surgical resection. doi: 10.1093/brain/awae141
Royer J, Larivi脙篓re S, Rodriguez-Cruces R, Cabalo DG, Tavakol S, Auer H, Ngo A, Park BY, Paquola C, Smallwood J, Jefferies E, Caciagli L, Bernasconi A, Bernasconi N, Frauscher B, Bernhardt BC. (2023) Cortical microstructural gradients capture memory network reorganization in temporal lobe epilepsy.Brain. doi: 10.1093/brain/awad125.
Larivi脙篓re S, Bayrak 脜啪, Vos de Wael R, Benkarim O, Herholz P, Rodriguez-Cruces R, Paquola C, Hong SJ, Misic B, Evans AC, Valk SL, Bernhardt BC (2023) BrainStat: A toolbox for brain-wide statistics and multimodal feature associations. Neuroimage. doi: 10.1016/j.neuroimage.2022.119807
Cruces RR, Royer J, Herholz P, Larivi脙篓re S, Vos de Wael R, Paquola C, Benkarim O, Park BY, Degr脙漏-Pelletier J, Nelson MC, DeKraker J, Leppert IR, Tardif C, Poline JB, Concha L, Bernhardt BC. (2022) Micapipe: A pipeline for multimodal neuroimaging and connectome analysis. doi: 10.1016/j.neuroimage.2022.119612
Paquola C, Amunts K, Evans A, Smallwood J, Bernhardt B. (2022) Closing the mechanistic gap: the value of microarchitecture in understanding cognitive networks. Trends Cogn Sci. doi: 10.1016/j.tics.2022.07.001
Bernhardt BC, Smallwood J, Keilholz S, Margulies DS. (2022) Gradients in brain organization. Neuroimage. doi: 10.1016/j.neuroimage.2022.118987
Larivi脙篓re S, Paquola C, Park BY, Royer J, Wang Y, Benkarim O, Vos de Wael R, Valk SL, Thomopoulos SI, Kirschner M, Lewis LB, Evans AC, Sisodiya SM, McDonald CR, Thompson PM, Bernhardt BC (2021) The ENIGMA Toolbox: multiscale neural contextualization of multisite neuroimaging datasets. Nat Methods. doi: 10.1038/s41592-021-01186-4.
Park BY, Hong SJ, Valk SL, Paquola C, Benkarim O, Bethlehem RAI, Di Martino A, Milham MP, Gozzi A, Yeo BTT, Smallwood J, Bernhardt BC. (2021) Differences in subcortico-cortical interactions identified from connectome and microcircuit models in autism. Nat Commun. doi: 10.1038/s41467-021-21732-0.
Paquola C, Vos De Wael R, Wagstyl K, Bethlehem RAI, Hong SJ, Seidlitz J, Bullmore ET, Evans AC, Misic B, Margulies DS, Smallwood J, Bernhardt BC. (2019) Microstructural and functional gradients are increasingly dissociated in transmodal cortices. PLoS Biol. doi: 10.1371/journal.pbio.3000284
Hong SJ, Vos de Wael R, Bethlehem RAI, Lariviere S, Paquola C, Valk SL, Milham MP, Di Martino A, Margulies DS, Smallwood J, Bernhardt BC. (2019) Atypical functional connectome hierarchy in autism. Nat Commun. doi: 10.1038/s41467-019-08944-1
Open Access toolboxes:
贬颈辫辫辞尘补辫蝉:听
DeKraker J, Cabalo DG, Royer J, Khan AR, Karat B, Benkarim O, Rodriguez-Cruces R, Frauscher B, Pana R, Hansen JY, Misic B, Valk SL, Kirschner M, Bernasconi A, Bernasconi N, Muenzig S, Axer M, Amunts K, Evans AC, Bernhardt BC (2024) HippoMaps: multiscale cartography of human hippocampal organization. biorxiv.
叠谤补颈苍厂迟补迟:听
Lariviere S, Bayrak S, Vos de Wael R, Benkarim O, Herholz P, Rodriguez-Cruces R, Paquola C, Hong S, Misic B, Evans AC, Valk SL, Bernhardt BC (2023) BrainStat: A toolbox for brain-wide statistics and neuroscientific contextualization. Neuroimage. 266: 119807
惭颈肠补笔颈辫别:听
Rodriguez-Cruces R, Royer J, Herholz P, Lariviere S, Vos de Wael R, Paquola C, Benkarim O, Park B, Degre-Pelletier J, Nelson MC, DeKraker J, Leppert IR, Tardif CL, Poline JB, Concha L, Bernhardt BC (2022) Micapipe: a pipeline for multimodal neuroimaging and connectome analysis. Neuroimage. 263: 119612
贰苍颈驳尘补-迟辞辞濒产辞虫:听
Lariviere S, Paquola C, Park B, Royer J, Wang Y, Benkarim O, Vos de Wael R, Valk S, Thomopoulos SI, Kirschner M, ENIGMA, Sisodiya S, McDonald CR, Thompson PM, Bernhardt BC (2021) The ENIGMA toolbox: multiscale neural contextualization of multisite neuroimaging datasets. Nature Methods, 18: 698-700
叠谤补颈苍厂辫补肠别:听
Vos de Wael R, Benkarim O, Paquola C, Larivi脙篓re S, Royer J, Tavakol S, Xu T, Hong S, Langs G, Valk S, Misic B, Milham M, Margulies D, Smallwood J, Bernhardt BC (2020) BrainSpace: a toolbox for the analysis of macroscale gradients in neuroimaging and connectomics datasets. Comms Biology, 3(1): 103-112
叠颈驳叠谤补颈苍奥补谤辫:听
Paquola C, Royer J, Lewis L, Lepage Claude, Glatard T, Wagstyl K, DeKraker K, Toussaint PJ, Valk S, Collins DL, Khan AR, Amunts K, Evans A, Dickscheid T, Bernhardt BC (2021) The BigBrainWarp toolbox for integration of BigBrain 3D histology with multimodal neuroimaging. eLife, 10: e70119
