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Study of velvet worm slime could revolutionize sustainable material design

9I制作厂免费 researchers want to harness a natural process that enables slime鈥檚 transformation from liquid to fibre and back again
Published: 19 March 2025

A new discovery about the slime ejected by velvet worms could revolutionize sustainable material design, according to a by 9I制作厂免费 researchers. Their findings outline how a naturally occurring protein structure, conserved across species from Australia, Singapore and Barbados over nearly 400 million years of evolution, enables the slime鈥檚 transformation from liquid to fibre and back again. It鈥檚 a discovery that could inspire next-generation recyclable bioplastics.

"Nature has already figured out a way to make materials that are both strong and recyclable,鈥 said Matthew Harrington, a chemistry professor and Canada Research Chair in green chemistry, who led the study. 鈥淏y decoding the molecular structure of velvet worm slime, we're now one step closer to replicating that efficiency for the materials we use every day."

Velvet worms, small caterpillar-like creatures found in humid forests of the southern hemisphere, use their slime to capture prey. When ejected, the slime rapidly hardens into fibres as strong as nylon. The slime dissolves in water and can be reconstituted into new fibres. Until now, the molecular mechanism behind this reversibility remained a mystery.

Using protein sequencing and AI-driven structure prediction (AlphaFold, the 2024 Nobel Prize-winning tool), Harrington鈥檚 team identified previously unknown proteins in the slime that function similarly to cell receptors in the immune system. The researchers believe the receptor proteins function to link large structural proteins during fibre formation. By comparing two subgroups of velvet worms that separated nearly 380 million years ago, the researchers demonstrated the evolutionary significance and functional relevance of this protein.

A blueprint for recyclable materials

Traditional plastics and synthetic fibres are typically made using petroleum-based precursors and require energy-intensive processes to manufacture and recycle, often involving heat or chemical treatments. The velvet worm, however, uses simple mechanical forces 聽pulling and stretching 鈥 to generate strong, durable fibres from biorenewable precursors, which can later be dissolved and reused without harmful byproducts.

鈥淥bviously, a plastic bottle that dissolves in water would have limited use, but by adjusting the chemistry of this binding mechanism, we can get around this issue,鈥 said Harrington.

The study was co-authored by researchers from 9I制作厂免费 and Nanyang Technological University (NTU) in Singapore. The team鈥檚 next challenge will be to experimentally verify the binding interactions and explore whether the principle can be adapted for engineered materials.

About the study

by Zhaolong Hu, Alexander Baer, Matthew J. Harrington, Ali Miserez et al., was published in Proceedings of the National Academy of Sciences (PNAS).

This research received funding from the Natural Sciences and Engineering Research Council of Canada and a Canada Research Chair award.

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